Data from a pharmacokinetics study of phenobarbital in neonatal infants. During the first few days of life the infants receive multiple doses of phenobarbital for prevention of seizures. At irregular intervals blood samples are drawn and serum phenobarbital concentrations are determined.
This data frame contains the following columns:
The data were originally given in Grasela and Donn (1985), "Neonatal
population pharmacokinetics of phenobarbital derived from routine
clinical data",
Developmental Pharmacology and Therapeutics,
8, 374-383.
They are also analysed in Boeckmann, Sheiner, and Beal
(1992), "NONMEM User's Guide, Part V, Introductory Guide", University
of California, San Francisco and in section 6.6 of Davidian and
Giltinan (1995), "Nonlinear Models for Repeated Measurement Data",
Chapman and Hall, London.
Pheno.nlme <- nlme(conc ~ Pheno.func(Subject, time, dose, lCl, lV), fixed = list(lCl ~ ., lV ~ .), random = list(lCl ~ ., lV ~ .), cluster = ~ Subject, data = Phenobarb, start = list(fixed = c(-5, 0)), na.pattern = ~ !is.na(conc), na.action = na.include)