The
Quinidine data frame is routine clinical data on patients
receiving the drug quinidine as a treatment for cardiac arrythmia
(atrial fibrillation of ventricular arrythmias). All patients were
receiving oral quinidine doses. At irregular intervals blood samples
were drawn and serum concentrations of quinidine were determined.
DATA DESCRIPTION:
This data frame contains the following columns:
VALUE:
Subject
a factor identifying the patient on whom the data were collected.
time
time (hr.) at which the drug was administered or the blood sample
drawn. This is measured from the time the patient entered
the study.
conc
serum quinidine concentration (mg/L).
dose
dose of drug administered (mg). Although there were two different
forms of quinidine administered, the doses were adjusted for
differences in salt content by conversion to milligrams of quinidine
base.
interval
the interval is recorded when the drug has been given at regular
intervals for a sufficiently long period of time to assume steady
state behaviour.
Age
age of the subject on entry to the study (yr).
Height
height of the subject on entry to the study (in).
Weight
body weight of the subject (kg).
Race
a factor with possible three levels:
Caucasian,
Black,
Latin.
Smoke
a factor giving smoking status at the time of the measurement:
no or
yes.
Ethanol
a factor giving ethanol (alcohol) abuse status at the time of the measurement:
none,
current, or
former.
Heart
a factor indicating congestive heart failure for the subject:
none or mild,
moderate, or
severe.
Creatinine
a factor in 8 levels coding the creatinine clearance and other
measurements. Creatinine clearance is divided into those greater than
50 mg/min and those less than 50 mg/min.
glyco
alpha-1 acid glycoprotein concentration (mg/dL). Often measured at
the same time as the quinidine concentration.
SOURCE:
These data were originally quoted in Verme, Lidden, Celmenti, and
Harris (1992), "Pharmacokinetics of quinidine in male patients: A
population analysis",
Clinical Pharmacokinetics, 22, 468-480.
They are analysed in several places including section 9.3 of Davidian
and Giltinan (1995), "Nonlinear Models for Repeated Measurement Data",
Chapman and Hall, London.