Pharmacokinetics Study of Phenobarbital

SUMMARY:

Data from a pharmacokinetics study of phenobarbital in neonatal infants. During the first few days of life the infants receive multiple doses of phenobarbital for prevention of seizures. At irregular intervals blood samples are drawn and serum phenobarbital concentrations are determined.

DATA DESCRIPTION:

This data frame contains the following columns:

VALUE:

Subject
a factor identifying the infant.
Wt
birth weight of the infant (kg).
Apgar
the 5-minute Apgar score for the infant. This is an indication of health of the newborn infant. The scale is 1 to 10.
time
time when the sample is drawn or drug administered (hr).
dose
dose of drug administered (ug/kg).
conc
phenobarbital concentration in the serum (ug/L).

SOURCE:

The data were originally given in Grasela and Donn (1985), "Neonatal population pharmacokinetics of phenobarbital derived from routine clinical data", Developmental Pharmacology and Therapeutics, 8, 374-383.

They are also analysed in Boeckmann, Sheiner, and Beal (1992), "NONMEM User's Guide, Part V, Introductory Guide", University of California, San Francisco and in section 6.6 of Davidian and Giltinan (1995), "Nonlinear Models for Repeated Measurement Data", Chapman and Hall, London.

SEE ALSO:

, .

EXAMPLES:

Pheno.nlme <-   
     nlme(conc ~ Pheno.func(Subject, time, dose, lCl, lV), 
     fixed = list(lCl ~ ., lV ~ .), 
     random = list(lCl ~ ., lV ~ .), 
     cluster = ~ Subject, 
     data = Phenobarb, 
     start = list(fixed = c(-5, 0)), 
     na.pattern = ~ !is.na(conc), 
     na.action = na.include)