Data from a study by Dr. Robert Upton of the kinetics of the anti-asthmatic drug Theophylline. Twelve subjects were given oral doses of Theophylline then serum concentrations were measured at 11 time points over the next 25 hours.
This data frame contains the following columns:
These data are reported in Boeckmann, Sheiner, and Beal (1992), "NONMEM User's Guide, Part V, Introductory Guide", University of California, San Francisco and in Davidian and Giltinan (1995), "Nonlinear Models for Repeated Measurement Data", Chapman and Hall, London.
Theoph.lis <- nlsList(conc ~ first.order.log(Dose, time, lCl, lka, lke), data = Theoph, cluster = ~ Subject) Theoph.nlme <- nlme(Theoph.lis)